Endocrine Abstracts

Background: Studies in adults have shown physiological protection of a ‘set-point’ for weight, explaining why obese adults who diet eventually regain weight.Objective: We hypothesised that set-points for weight, and their physiological defence, are flexible in childhood but become fixed around puberty. We aimed to show that obese children who lost weight had less ‘reflex’ changes in satiety hormone profiles (that would drive weight re...

Background: In obese adults, caloric restriction leads to a reduction in energy expenditure, and it is this compensatory adaptive down-regulation that is cited as one of the causes of weight regain in adults. There are currently insufficient data to establish if this phenomenon also occurs in obese children who lose weight and whether puberty affects this adaptive response.Objective: We hypothesised that obese children who lose weight have less ‘ref...